The repertoire of IgE⁺ PCs is more closely related to IgG1⁺ GC B cells than IgE⁺ GC B cells.

<p>(A) Overlap between the 50 most frequent CDR3 sequences in IgE⁺ PCs with the same CDR3 sequences in the IgG1⁺ or IgE⁺ GC B cell repertoire. Bars show the mean frequency + SD of CDR3 sequences in IgE⁺ PCs for which corresponding CDR3 sequences were detected in the IgE⁺ or IgG1⁺ GC B cell repertoires. *<i>p</i> < 0.05 by Student’s <i>t</i> test. (B and C) Frequency of SHMs and distribution of silent and nonsilent mutations in VH sequences of sorted IgE-GC (red) and IgG1-GC (blue) B cells (B) or IgE-PC (red) and IgG1-PC (blue) (C). Bars show the mean + standard error of the mean (SEM) of samples from three individual mice.