Additional file 3: Figure S3. of Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

AQP4 deficiency did not affect LRP1 expression by neurons in APP/PS1 mice. (A) LRP1 immunohistochemistry. High expression of LRP1 was localized to the cell membrane of pyramidal neurons in 12-month old AQP4−/−APP/PS1 mice and APP/PS1 mice. Some glial-like cells (inserted high magnification images) distal to the plaques were also positive for LRP1 in the two genotype mice. (C) Quantitative analysis of the percentage of LRP-1 positive area in the hippocampus and cerebral cortex. (B) Western bolt and (D) densitometry analysis of LRP1 protein levels in the hippocampus and cortex. Data represent mean ± SEM from 5–6 mice (3–4 female, and 1–2 male) per group. The statistical analysis was performed by Student’s t-test. (TIF 3855 kb