Gene expression of BDNF across the whole brain as assessed in Allen Brain Atlas (Seattle, WA, USA).

<p>In mice, gene expression was the highest in the DG/hippocampus as investigated by In Situ Hybridization (ISH), where warm colors indicate high expression. Note that contrast and brightness were enhanced in original images to increase visibility of the effects here. Black bars correspond to 2 mm. Gene expression in humans is shown as individually normalized gene expression (<i>Z</i>-scores normalized to whole human brain expression). The heat map shows scores across the whole human brain and for each of the six subjects contained in the database beside each other, where red indicates high and green indicates low expression. Bars represent mean normalized gene expression and standard deviation across one female and five male subjects included. Search conducted on 17^th October 2014 for human and on 9^th October 2014 for mice data. *** <i>P</i> < 0.001; ** <i>P</i> < 0.01; * <i>P</i> < 0.05, two-tailed Student’s <i>t</i>-test against 0. For details on the methods we refer to Mueller <i>et al</i>.[<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141564#pone.0141564.ref053" target="_blank">53</a>]