A systemic inflammatory response (SIR) strongly modulates CHI3L1, CHIA and CHIT expression in a mouse model of burn injury and sepsis.

<p>WT mice were exposed to burn injury (20% <u>B</u>ody <u>S</u>urface <u>A</u>rea), lipopolysaccharide (LPS) or oral gavage with Pseudomonas strain (PA14) 48 hours prior to tissue analysis. (A) CHI3L1 expression was strongly induced in lung tissue under all conditions of SIR but also in colon following exposure to PA14 strain. (B) CHIA was predominately induced in liver but also colon following exposure to PA14 strain. (C) CHIT1 appeared to be induced in spleen and liver by burn injury, with or without LPS and PA14 exposure (all: qPCR /ΔΔCt-method: n≥4; mean±SD; normalized to respective organ control).