MaBoSS simulation of wild type, of individual mutations of p53 and NICD and of the double mutant.

<p>The probabilities associated with each phenotype represent the number of stochastic simulations leading to each phenotype from pre-defined initial conditions. A. Wild type, see text. B. p53 LoF, same phenotypes found in (A) are reachable but with different probabilities than wild type conditions. C. NICD GoF, apoptosis is no longer reachable. D. p53 LoF and NICD GoF, only metastasis is observed. Note that HS stands for “Homeostatic State” and CCA for “CellCycleArrest.”