Key results and author conclusions from studies that compared baseline characteristics between a real-world patient population and a patient sample enrolled in an RCT (Method A). Detailed description of results and subjective author conclusions from studies included in the review that employed Method A. (PDF 207 kb
Table S1. Characteristics of respondents and their experiences with regulatory data. Table S2.Charac...
Title of data. Detailed description of systematic review methodology: Description of data: This atta...
Best evidence synthesis: sensitivity analysis. Sensitivity analysis with regard to the impact of lar...
Key results and main author conclusions from studies assessing rates of ineligibility for RCT partic...
Summary of real-world and RCT data sources employed in included studies. Detailed description of dat...
Trials with long-term follow-up excluded from final analysis. *open-label study investigating safety...
Determination of the characteristics of the sixty-six randomised clinical trials in this review. Dat...
Listing of the sixty-six randomised clinical trials in this review. A citation listing by journal. (...
Table S1. Pivotal trials with at least one postapproval trial with a patient-relevant outcome. (XLSX...
Appendix 1. List of participants. Appendix 2. Results—Spider diagrams of mean vignette scores per in...
Risk of bias shown in each domain for an individual randomised controlled trial (RCT). Red indicates...
Included studies and the information extracted from them, along with the records from each of the ma...
Median (Interquartile range (IQR)) absolute bias (%) for treatment effect, β1 for different approac...
Further characteristics of studies that adopted a stepped wedge randomised controlled trial design i...
Appendix 1. Literature search for MEDLINE. Appendix 2. Data abstraction process from identified stud...
Table S1. Characteristics of respondents and their experiences with regulatory data. Table S2.Charac...
Title of data. Detailed description of systematic review methodology: Description of data: This atta...
Best evidence synthesis: sensitivity analysis. Sensitivity analysis with regard to the impact of lar...
Key results and main author conclusions from studies assessing rates of ineligibility for RCT partic...
Summary of real-world and RCT data sources employed in included studies. Detailed description of dat...
Trials with long-term follow-up excluded from final analysis. *open-label study investigating safety...
Determination of the characteristics of the sixty-six randomised clinical trials in this review. Dat...
Listing of the sixty-six randomised clinical trials in this review. A citation listing by journal. (...
Table S1. Pivotal trials with at least one postapproval trial with a patient-relevant outcome. (XLSX...
Appendix 1. List of participants. Appendix 2. Results—Spider diagrams of mean vignette scores per in...
Risk of bias shown in each domain for an individual randomised controlled trial (RCT). Red indicates...
Included studies and the information extracted from them, along with the records from each of the ma...
Median (Interquartile range (IQR)) absolute bias (%) for treatment effect, β1 for different approac...
Further characteristics of studies that adopted a stepped wedge randomised controlled trial design i...
Appendix 1. Literature search for MEDLINE. Appendix 2. Data abstraction process from identified stud...
Table S1. Characteristics of respondents and their experiences with regulatory data. Table S2.Charac...
Title of data. Detailed description of systematic review methodology: Description of data: This atta...
Best evidence synthesis: sensitivity analysis. Sensitivity analysis with regard to the impact of lar...