Nef<sub>9–19</sub>, Nef<sub>89–97</sub>, Nef<sub>193–203</sub>, and Vif<sub>114–124</sub> epitope-specific CD8<sup>+</sup> T-cell responses in SIV controllers.
- Takushi Nomura (288970)
- Hiroyuki Yamamoto (31403)
- Hiroshi Ishii (314726)
- Hirofumi Akari (670552)
- Taeko K. Naruse (288994)
- Akinori Kimura (245540)
- Tetsuro Matano (31407)
Publication date
November 2015
DOIAbstract
<p>(A) Frequencies of CD8<sup>+</sup> T cells specific for SIV Nef<sub>9–19</sub>, Nef<sub>89–97</sub>, Nef<sub>193–203</sub>, and Vif<sub>114–124</sub> epitopes in Group M (upper panels) and Group N (lower) at 4 months (4M), 1 year (1Y), and 2 years (2Y) post-infection. (B) Comparisons of the sum of Nef<sub>9–19</sub>-, Nef<sub>89–97</sub>-, Nef<sub>193–203</sub>-, and Vif<sub>114–124</sub>-specific CD8<sup>+</sup> T-cell frequencies at 4M, 1Y, and 2Y between Groups M and N. The sum of CD8<sup>+</sup> T-cell frequencies specific for these epitopes in Group M was significantly higher compared to Group N at 2Y post-infection (p = 0.0190 by Mann-Whitney U-test).</p
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