Levels of TNF-α, caspase-3, IL-6, and superoxide dismutase in HEK293 cells lysates treated with vehicle, cisplatin (Cis, 10 μM), cisplatin+pioglitazone (PIO, 10 μM), cisplatin+fenofibrate (Feno, 10 μM), cisplatin+pioglitazone+fenofibrate, cisplatin+thalidomide (Thalid, 10 μM), and cisplatin+pioglitazone+fenofibrate+thalidomide.

<p>All drugs were incubated for 24 hr. Values are means±S.E.M. of 5 replicas. <b>*, ⁺, ^#</b>, ^π, ^$ and ^% denote significant difference (P<0.05) vs. control, cisplatin, cisplatin+pioglitazone, cisplatin+fenofibrate cisplatin+pioglitazone+fenofibrate and cisplatin+thalidomide values, respectively.