<div><p>Though evidence is mounting that a major function of sleep is to maintain brain plasticity and consolidate memory, little is known about the molecular pathways by which learning and sleep processes intercept. Anaplastic lymphoma kinase (<i>Alk</i>), the gene encoding a tyrosine receptor kinase whose inadvertent activation is the cause of many cancers, is implicated in synapse formation and cognitive functions. In particular, <i>Alk</i> genetically interacts with <i>Neurofibromatosis 1</i> (<i>Nf1</i>) to regulate growth and associative learning in flies. We show that <i>Alk</i> mutants have increased sleep. Using a targeted RNAi screen we localized the negative effects of <i>Alk</i> on sleep to the mushroom body, a structure importa...
Amino acids are newly emerging as sleep supplements yet their neural and molecular bases underlying ...
Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry ...
Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry ...
Anaplastic Lymphoma Kinase (Alk) is a Receptor Tyrosine Kinase (RTK) activated in several cancers, b...
Inhibition of signalling through several receptor tyrosine kinases (RTKs), including the insulin-lik...
Background: Extended wakefulness disrupts acquisition of short-term memories in mammals. However, th...
Sleep is a unique behavioral state that is conserved between species, and sleep regulation is closel...
Early life sleep is critical for normal development of neural circuits. Despite the diversity in pre...
<div><p>Considerable evidence indicates that sleep is essential for learning and memory. <i>Drosophi...
While sleep is conserved across evolution, the function or functions of sleep remain unknown. Notabl...
SummaryDeveloping animals survive periods of starvation by protecting the growth of critical organs ...
SummaryBackgroundExtended wakefulness disrupts acquisition of short-term memories in mammals. Howeve...
Considerable evidence indicates that sleep is essential for learning and memory. Drosophila melanoga...
Dysregulation of sleep and feeding has widespread health consequences. Despite extensive epidemiolog...
Dysregulation of sleep and feeding has widespread health consequences. Despite extensive epidemiolog...
Amino acids are newly emerging as sleep supplements yet their neural and molecular bases underlying ...
Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry ...
Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry ...
Anaplastic Lymphoma Kinase (Alk) is a Receptor Tyrosine Kinase (RTK) activated in several cancers, b...
Inhibition of signalling through several receptor tyrosine kinases (RTKs), including the insulin-lik...
Background: Extended wakefulness disrupts acquisition of short-term memories in mammals. However, th...
Sleep is a unique behavioral state that is conserved between species, and sleep regulation is closel...
Early life sleep is critical for normal development of neural circuits. Despite the diversity in pre...
<div><p>Considerable evidence indicates that sleep is essential for learning and memory. <i>Drosophi...
While sleep is conserved across evolution, the function or functions of sleep remain unknown. Notabl...
SummaryDeveloping animals survive periods of starvation by protecting the growth of critical organs ...
SummaryBackgroundExtended wakefulness disrupts acquisition of short-term memories in mammals. Howeve...
Considerable evidence indicates that sleep is essential for learning and memory. Drosophila melanoga...
Dysregulation of sleep and feeding has widespread health consequences. Despite extensive epidemiolog...
Dysregulation of sleep and feeding has widespread health consequences. Despite extensive epidemiolog...
Amino acids are newly emerging as sleep supplements yet their neural and molecular bases underlying ...
Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry ...
Sleep is important for memory consolidation and is responsive to waking experience. Clock circuitry ...