Relative abundance of dinucleotides in papillomaviruses and polyomaviruses.

<p>(a) The mean value for each dinucleotides O/E ratio (closed circles) are plotted for papillomaviruses. Among all the dinucleotide, CpG dinucleotides were clearly depleted among papillomaviruses (b) The mean value for each dinucleotides O/E ratio (closed circles) are plotted for polyomaviruses. CpG dinucleotide depletion is pronounced among polyomaviruses. (c) Among papillomaviruses, those infecting humans or other mammals (mammals other than humans) had significantly lower CpG O/E ratios than those infecting aves/reptiles [0.48 (95% CI of 0.47 to 0.5) vs 0.77(95% CI of 0.67 to 0.87); P<0.0001 and 0.51 (95% CI of 0.48 to 0.54) vs 0.77(95% CI of 0.67 to 0.87) P = 0.0004]. The relative abundance of CpG dinucleotides among papillomaviruses infecting humans was marginally lower than that of those infecting other mammals, this difference was not significant [0.48 (95% CI of 0.47 to 0.5) vs 0.51 (95% CI of 0.48 to 0.54), P = 0.1736]. (d) Polyomaviruses infecting humans were significantly CpG depleted as compared to those infecting other mammals [0.12(95% CI of 0.1 to 0.15) vs 0.20(95% CI of 0.16 to 0.24); P = 0.005] or aves [0.12(95% CI of 0.1 to 0.15) vs 0.44(95% CI of 0.3 to 0.57); P = 0.0007].