Granule cell firing in response to HFS and associated homeostatic adjustment of LTP and LTD amplitudes before, during (horizontal black bars) and after HFS.

<p>(A) The integrated spike count and thus also potentiation as well as depression amplitudes (A_p, A_d) remained steady during 400-DBS. (B) 100-TBS generated more spikes during the HFS than the DBS protocol (see also <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004588#pcbi.1004588.g005" target="_blank">Fig 5</a>). In response to the increased spike count during 100-TBS, potentiation and depression amplitudes were rapidly and strongly decreased and increased, respectively. (C) 400-TBS generated fewer spikes than 100-TBS (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004588#pcbi.1004588.g005" target="_blank">Fig 5</a>) resulting in smaller homeostatic changes in potentiation and depression amplitude. See text for details.