Brain tissue loss induced by hypoxia-ischemia in 7 day-old rats and evaluated at P14.

<p>Representative stereomicroscopic photographs of 5 μm Nissl-stained brain sections (interaural distance 5.40 mm and bregma -3.60 mm) are shown. (<b>A</b>) Control group with normal morphological brain (n = 8). (<b>B</b>) HI brain with evident loss of tissue in the ipsilateral side of the cortex, and with obvious damage to the hippocampus (region indicated by arrows) (n = 10). (<b>C</b>) Brain treated with resveratrol 10 minutes before hypoxia, which is similar to the control brain (n = 10). (<b>D</b>) HI brain treated with resveratrol immediately after hypoxia, with obvious signs of infarct, as denoted by the arrow (n = 10). Scale bar: 2.5 mm. The histogram illustrates percentage of tissue loss is expressed. Asterisks denote the significance levels when compared to the control group (**<b>*</b><i>P</i><0.0001). The hash denotes the significance levels when compared to the HI group (^###<i>P</i><0.0001).