Dexra prevents DXR-induced dsDNA breaks in ovarian cells.

<p>Neutral comet assay was performed on the indicated cell types. Panel <b><i>A</i></b> quantifies dsDNA breaks in granulosa-enriched cell populations at time points from 0–24 h post-DXR injection. Panel <b><i>B</i></b> quantifies dsDNA breaks in stromal/thecal-enriched cell populations at time points from 0–24 h post-DXR injection. Panel <b><i>C</i></b> bar graph quantifies dsDNA breaks in oocytes at 24 h post-DXR injection. n = 3 mice/group/point, per replicate, 4 replicates. * p< 0.05, one-way ANOVA. The control and DXR-only treatment groups adapted from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142588#pone.0142588.ref027" target="_blank">27</a>].