A delay in viral spread is observed in brain of rOC/S<sub>G758R</sub> -infected mice compared to rOC/ATCC after intranasal inoculation in 10 day-old BALB/c mice.
- Alain Le Coupanec (421447)
- Marc Desforges (823481)
- Mathieu Meessen-Pinard (823482)
- Mathieu Dubé (74209)
- Robert Day (266252)
- Nabil G. Seidah (148050)
- Pierre J. Talbot (823483)
Publication date
November 2015
DOIAbstract
<p>Histological examination of virus spread within the brain of 10-day old BALB/c mice infected with 10<sup>3.25</sup> TCID<sub>50</sub>/10μL of rOC/ATCC or rOC/S<sub>G758R</sub>, or PBS by the IN route. (A) Detection of viral antigens in the olfactory bulb of infected mice at 5 and 7 dpi. (B) Detection of viral antigens in the hippocampus of infected mice at 7 and 9 dpi. Magnification 40x.</p
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