In this work, we introduce dipeptides containing tryptophan <i>N</i>-capped with the nonsteroidal anti-inflammatory drug naproxen and <i>C</i>-terminal dehydroamino acids, dehydrophenylalanine (ΔPhe), dehydroaminobutyric acid (ΔAbu), and dehydroalanine (ΔAla) as efficacious protease resistant hydrogelators. Optimized conditions for gel formation are reported. Transmission electron microscopy experiments revealed that the hydrogels consist of networks of micro/nanosized fibers formed by peptide self-assembly. Fluorescence and circular dichroism spectroscopy indicate that the self-assembly process is driven by stacking interactions of the aromatic groups. The naphthalene groups of the naproxen moieties are highly organized in the fibers throu...
Joel P. SchneiderHydrogels are heavily hydrated, viscoelastic, porous materials that show promise a...
This work reports the self-assembly of a sparingly soluble antibiotic (ciprofloxacin) and a hydropho...
A library of Cbz-protected dehydrodipeptides was synthesised and evaluated as minimalist hydrogels. ...
In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-inf...
In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-infl...
Peptide-based self-assembled hydrogels have triggered remarkable research interest in recent years ...
Supramolecular hydrogels rely on small molecules that self-assemble in water as a result of the coo...
In this work, several new hydrogelators were developed, containing a Naproxen or a Naphthalene group...
In this work, several new hydrogelators were developed, containing a Naproxen or a Naphthalene group...
Self-assembled peptide hydrogels have emerged in recent years as the new paradigm in biomaterials re...
5siSupramolecular hydrogels offer interesting opportunities for co-assembly with drugs towards susta...
Employing amino acids and peptides as molecular building blocks provides unique opportunities for ge...
Self-assembled low molecular weight peptide hydrogels have emerged in recent years as the new paradi...
The development of strategies to minimise the adverse side-effects of non-steroidal anti-inflammator...
Short peptides capped on the N-terminus with aromatic groups are often able to form supramolecular h...
Joel P. SchneiderHydrogels are heavily hydrated, viscoelastic, porous materials that show promise a...
This work reports the self-assembly of a sparingly soluble antibiotic (ciprofloxacin) and a hydropho...
A library of Cbz-protected dehydrodipeptides was synthesised and evaluated as minimalist hydrogels. ...
In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-inf...
In this work, we introduce dipeptides containing tryptophan N-capped with the nonsteroidal anti-infl...
Peptide-based self-assembled hydrogels have triggered remarkable research interest in recent years ...
Supramolecular hydrogels rely on small molecules that self-assemble in water as a result of the coo...
In this work, several new hydrogelators were developed, containing a Naproxen or a Naphthalene group...
In this work, several new hydrogelators were developed, containing a Naproxen or a Naphthalene group...
Self-assembled peptide hydrogels have emerged in recent years as the new paradigm in biomaterials re...
5siSupramolecular hydrogels offer interesting opportunities for co-assembly with drugs towards susta...
Employing amino acids and peptides as molecular building blocks provides unique opportunities for ge...
Self-assembled low molecular weight peptide hydrogels have emerged in recent years as the new paradi...
The development of strategies to minimise the adverse side-effects of non-steroidal anti-inflammator...
Short peptides capped on the N-terminus with aromatic groups are often able to form supramolecular h...
Joel P. SchneiderHydrogels are heavily hydrated, viscoelastic, porous materials that show promise a...
This work reports the self-assembly of a sparingly soluble antibiotic (ciprofloxacin) and a hydropho...
A library of Cbz-protected dehydrodipeptides was synthesised and evaluated as minimalist hydrogels. ...