Homogeneity/Heterogeneity analysis of FGFR1 amplified tumors.

Comparative Lesions Analysis Through a Targeted Sequencing Approach

VICENTINI, CARLO ALBERTO
Mafficini A.
Simbolo M.
Fassan M.
Delfino P.
Lawlor R. T.
Rusev B.
Scarpa A.
Corbo V.

January 2019

Assessing intra-tumoral heterogeneity (ITH) is of paramount importance to anticipate failure of targ...

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.

Andor, N.
Graham, T.A.
Jansen, M.A.
Xia, L.C.
Aktipis, C.A.
Petritsch, C.
Ji, H.P.
Maley, C.C.

January 2016

Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the...

Mutation, selection, and clonal expansion in tumor development leads to genomic heterogeneity between cells in a tumor.

Benjamin J. Raphael (44576)

December 2012

Current DNA sequencing approaches sequence DNA from many cells and thus result in a heterogenous ...

FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma.

Katharina von Loga
Jule Kohlhaussen
Lia Burkhardt
Ronald Simon
Stefan Steurer
Susanne Burdak-Rothkamm
Frank Jacobsen
Guido Sauter
Till Krech

Amplification of the fibroblast growth factor receptor 1 (FGFR1) is believed to predict response to ...

FGFR2-amplified tumor clones are markedly heterogeneously distributed in carcinomas of the upper gastrointestinal tract

Albin, Jan
Fahrig, Luca
Siemanowski, Janna
Rehkaemper, Jan
Gebauer, Florian
Zander, Thomas
Buettner, Reinhard
Bruns, Christiane Josephine
Schroeder, Wolfgang
Alakus, Hakan
Hieggelke, Lena
Quaas, Alexander

Background FGFR2 is a therapy-relevant target in tumors of the upper gastrointestinal tract (GIT), a...

Tumour Heterogeneity: The Key Advantages of Single-Cell Analysis

Marta Tellez-Gabriel
Benjamin Ory
Francois Lamoureux
Marie-Francoise Heymann
Dominique Heymann

December 2016

Tumour heterogeneity refers to the fact that different tumour cells can show distinct morphological ...

An illustration of heterogeneity distribution of each biomarker.

Peng Ye (141138)
Meizhuo Zhang (776382)
Shuqiong Fan (776381)
Tianwei Zhang (169823)
Haihua Fu (776383)
Xinying Su (776388)
Paul R. Gavine (776386)
Qiang Liu (166143)
Xiaolu Yin (776384)

November 2015

Heterogeneity distribution of MET protein expression (A), MET average gene copy num...

FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma

Katharina von Loga (500695)
Jule Kohlhaussen (824183)
Lia Burkhardt (824184)
Ronald Simon (997)
Stefan Steurer (514479)
Susanne Burdak-Rothkamm (824185)
Frank Jacobsen (22692)
Guido Sauter (124861)
Till Krech (121538)

November 2015

<div>Background and AimsAmplification of the fibroblast growth factor receptor 1 (<...

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer

Schildhaus, Hans-Ulrich
Heukamp, Lukas C.
Merkelbach-Bruse, Sabine
Riesner, Katharina
Schmitz, Katja
Binot, Elke
Paggen, Ellen
Albus, Kerstin
Schulte, Wolfgang
Ko, Yon-Dschun
Schlesinger, Andreas
Ansen, Sascha
Engel-Riedel, Walburga
Brockmann, Michael
Serke, Monika
Gerigk, Ulrich
Huss, Sebastian
Goeke, Friederike
Perner, Sven
Hekmat, Khosro
Frank, Konrad F.
Reiser, Marcel
Schnell, Roland
Bos, Marc
Mattonet, Christian
Sos, Martin
Stoelben, Erich
Wolf, Juergen
Zander, Thomas
Buettner, Reinhard

January 2012

We recently reported fibroblast growth factor receptor-type 1 (FGFR1) amplification to be associated...

Pre-analytics and tumor heterogeneity

September 2019

2When dealing with pre-analytics for tissues, it is often that case that tissue heterogeneity, and ...

Computational Analysis of Tumour Heterogeneity

Friedrich, Stefanie

January 2020

Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological s...

A community effort to create standards for evaluating tumor subclonal reconstruction

Salcedo, Adriana
Tarabichi, Maxime
Espiritu, Shadrielle Melijah G.
Deshwar, Amit G.
David, Matei
Wilson, Nathan M.
Dentro, Stefan
Wintersinger, Jeff A.
Liu, Lydia Y.
Ko, Minjeong
Sivanandan, Srinivasan
Zhang, Hongjiu
Zhu, Kaiyi
Ou Yang, Tai-Hsien
Chilton, John M.
Buchanan, Alex
Lalansingh, Christopher M.
P'ng, Christine
Anghel, Catalina V.
Umar, Imaad
Lo, Bryan
Zou, William
Simpson, Jared T.
Stuart, Joshua M.
Anastassiou, Dimitris
Guan, Yuanfang
Ewing, Adam D.
Ellrott, Kyle
Wedge, David C.
Morris, Quaid
Van Loo, Peter
Boutros, Paul C.
Jha, Alokkumar
Huang, Tanxiao
Yang, Tsun-Po
Peifer, Martin
Sahinalp, Cenk
Malikic, Salem
Vazquez-Garcia, Ignacio
Mustonen, Ville
Yang, Hsih-Te
Lee, Ken-Ray
Ji, Yuan
Sengupta, Subhajit
Rudewicz, Justine
Nikolski, Macha
Schaeverbeke, Quentin
Yuan, Ke
Markowetz, Florian
Macintyre, Geoff
Cmero, Marek
Chaudhary, Belal
Leshchiner, Ignaty
Livitz, Dimitri
Getz, Gad
Loher, Phillipe
Yu, Kaixian
Wang, Wenyi
Zhu, Hongtu

January 2020

Methods for reconstructing tumor evolution are benchmarked in the DREAM Somatic Mutation Calling Tum...

The Intra-Tumour Heterogeneity Landscape of Human Cancers

Dentro, Stefan Christiaan

January 2020

Tumours accumulate many somatic mutations in their lifetime. Some of these mutations, drivers, conve...

Tumor tissues and sibling cultures of patient CC0514 display genetic heterogeneity and heterogeneous mRNA expression profiles.

Dirk Schumacher (3080862)
Geoffroy Andrieux (176109)
Karsten Boehnke (6528593)
Marlen Keil (6528596)
Alessandra Silvestri (785503)
Maxine Silvestrov (6528599)
Ulrich Keilholz (3494126)
Johannes Haybaeck (233208)
Gerrit Erdmann (193638)
Christoph Sachse (6528602)
Markus Templin (3639934)
Jens Hoffmann (222702)
Melanie Boerries (381256)
Reinhold Schäfer (57658)
Christian R. A. Regenbrecht (559740)

April 2019

Heterogeneity of tumor tissues and PD3D sibling cultures was evaluated on DNA and mRNA levels. (A) O...

A community effort to create standards for evaluating tumor subclonal reconstruction.

Salcedo, Adriana
Tarabichi, Maxime
Espiritu, Shadrielle Melijah SMG
Deshwar, Amit G
David, Matei
Wilson, Nathan M
Dentro, Stefan
Wintersinger, Jeff J.A.
Liu, Leibao
Ko, Minjeong
Sivanandan, Srinivasan
Zhang, Hongjiu
Zhu, Kaiyi
Ou Yang, Tai-Hsien
Chilton, John JM
Buchanan, Alex
Lalansingh, Christopher CM
P'ng, Christine
Anghel, Catalina CV
Umar, Imaad
Lo, Bryan
Zou, William
DREAM SMC-Het Participants
Simpson, Jared T
Stuart, Joshua M
Anastassiou, Dimitris
Guan, Yuanfang
Ewing, Adam D
Ellrott, Kyle
Wedge, David C
Morris, Quaid
Van Loo, Peter
Boutros, Paul C

February 2020

Tumor DNA sequencing data can be interpreted by computational methods that analyze genomic heterogen...

Comparative Lesions Analysis Through a Targeted Sequencing Approach

VICENTINI, CARLO ALBERTO
Mafficini A.
Simbolo M.
Fassan M.
Delfino P.
Lawlor R. T.
Rusev B.
Scarpa A.
Corbo V.

January 2019

Assessing intra-tumoral heterogeneity (ITH) is of paramount importance to anticipate failure of targ...

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.

Andor, N.
Graham, T.A.
Jansen, M.A.
Xia, L.C.
Aktipis, C.A.
Petritsch, C.
Ji, H.P.
Maley, C.C.

January 2016

Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the...

Mutation, selection, and clonal expansion in tumor development leads to genomic heterogeneity between cells in a tumor.

Benjamin J. Raphael (44576)

December 2012

Current DNA sequencing approaches sequence DNA from many cells and thus result in a heterogenous ...

FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma.

Katharina von Loga
Jule Kohlhaussen
Lia Burkhardt
Ronald Simon
Stefan Steurer
Susanne Burdak-Rothkamm
Frank Jacobsen
Guido Sauter
Till Krech

Amplification of the fibroblast growth factor receptor 1 (FGFR1) is believed to predict response to ...

FGFR2-amplified tumor clones are markedly heterogeneously distributed in carcinomas of the upper gastrointestinal tract

Albin, Jan
Fahrig, Luca
Siemanowski, Janna
Rehkaemper, Jan
Gebauer, Florian
Zander, Thomas
Buettner, Reinhard
Bruns, Christiane Josephine
Schroeder, Wolfgang
Alakus, Hakan
Hieggelke, Lena
Quaas, Alexander

Background FGFR2 is a therapy-relevant target in tumors of the upper gastrointestinal tract (GIT), a...

Tumour Heterogeneity: The Key Advantages of Single-Cell Analysis

Marta Tellez-Gabriel
Benjamin Ory
Francois Lamoureux
Marie-Francoise Heymann
Dominique Heymann

December 2016

Tumour heterogeneity refers to the fact that different tumour cells can show distinct morphological ...

An illustration of heterogeneity distribution of each biomarker.

Peng Ye (141138)
Meizhuo Zhang (776382)
Shuqiong Fan (776381)
Tianwei Zhang (169823)
Haihua Fu (776383)
Xinying Su (776388)
Paul R. Gavine (776386)
Qiang Liu (166143)
Xiaolu Yin (776384)

November 2015

Heterogeneity distribution of MET protein expression (A), MET average gene copy num...

FGFR1 Amplification Is Often Homogeneous and Strongly Linked to the Squamous Cell Carcinoma Subtype in Esophageal Carcinoma

Katharina von Loga (500695)
Jule Kohlhaussen (824183)
Lia Burkhardt (824184)
Ronald Simon (997)
Stefan Steurer (514479)
Susanne Burdak-Rothkamm (824185)
Frank Jacobsen (22692)
Guido Sauter (124861)
Till Krech (121538)

November 2015

<div>Background and AimsAmplification of the fibroblast growth factor receptor 1 (<...

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer

Schildhaus, Hans-Ulrich
Heukamp, Lukas C.
Merkelbach-Bruse, Sabine
Riesner, Katharina
Schmitz, Katja
Binot, Elke
Paggen, Ellen
Albus, Kerstin
Schulte, Wolfgang
Ko, Yon-Dschun
Schlesinger, Andreas
Ansen, Sascha
Engel-Riedel, Walburga
Brockmann, Michael
Serke, Monika
Gerigk, Ulrich
Huss, Sebastian
Goeke, Friederike
Perner, Sven
Hekmat, Khosro
Frank, Konrad F.
Reiser, Marcel
Schnell, Roland
Bos, Marc
Mattonet, Christian
Sos, Martin
Stoelben, Erich
Wolf, Juergen
Zander, Thomas
Buettner, Reinhard

January 2012

We recently reported fibroblast growth factor receptor-type 1 (FGFR1) amplification to be associated...

Pre-analytics and tumor heterogeneity

September 2019

2When dealing with pre-analytics for tissues, it is often that case that tissue heterogeneity, and ...

Computational Analysis of Tumour Heterogeneity

Friedrich, Stefanie

January 2020

Every tumour is unique and characterised by its genetic, epigenetic, phenotypic, and morphological s...

A community effort to create standards for evaluating tumor subclonal reconstruction

Salcedo, Adriana
Tarabichi, Maxime
Espiritu, Shadrielle Melijah G.
Deshwar, Amit G.
David, Matei
Wilson, Nathan M.
Dentro, Stefan
Wintersinger, Jeff A.
Liu, Lydia Y.
Ko, Minjeong
Sivanandan, Srinivasan
Zhang, Hongjiu
Zhu, Kaiyi
Ou Yang, Tai-Hsien
Chilton, John M.
Buchanan, Alex
Lalansingh, Christopher M.
P'ng, Christine
Anghel, Catalina V.
Umar, Imaad
Lo, Bryan
Zou, William
Simpson, Jared T.
Stuart, Joshua M.
Anastassiou, Dimitris
Guan, Yuanfang
Ewing, Adam D.
Ellrott, Kyle
Wedge, David C.
Morris, Quaid
Van Loo, Peter
Boutros, Paul C.
Jha, Alokkumar
Huang, Tanxiao
Yang, Tsun-Po
Peifer, Martin
Sahinalp, Cenk
Malikic, Salem
Vazquez-Garcia, Ignacio
Mustonen, Ville
Yang, Hsih-Te
Lee, Ken-Ray
Ji, Yuan
Sengupta, Subhajit
Rudewicz, Justine
Nikolski, Macha
Schaeverbeke, Quentin
Yuan, Ke
Markowetz, Florian
Macintyre, Geoff
Cmero, Marek
Chaudhary, Belal
Leshchiner, Ignaty
Livitz, Dimitri
Getz, Gad
Loher, Phillipe
Yu, Kaixian
Wang, Wenyi
Zhu, Hongtu

January 2020

Methods for reconstructing tumor evolution are benchmarked in the DREAM Somatic Mutation Calling Tum...

The Intra-Tumour Heterogeneity Landscape of Human Cancers

Dentro, Stefan Christiaan

January 2020

Tumours accumulate many somatic mutations in their lifetime. Some of these mutations, drivers, conve...

Tumor tissues and sibling cultures of patient CC0514 display genetic heterogeneity and heterogeneous mRNA expression profiles.

Dirk Schumacher (3080862)
Geoffroy Andrieux (176109)
Karsten Boehnke (6528593)
Marlen Keil (6528596)
Alessandra Silvestri (785503)
Maxine Silvestrov (6528599)
Ulrich Keilholz (3494126)
Johannes Haybaeck (233208)
Gerrit Erdmann (193638)
Christoph Sachse (6528602)
Markus Templin (3639934)
Jens Hoffmann (222702)
Melanie Boerries (381256)
Reinhold Schäfer (57658)
Christian R. A. Regenbrecht (559740)

April 2019

Heterogeneity of tumor tissues and PD3D sibling cultures was evaluated on DNA and mRNA levels. (A) O...

A community effort to create standards for evaluating tumor subclonal reconstruction.

Salcedo, Adriana
Tarabichi, Maxime
Espiritu, Shadrielle Melijah SMG
Deshwar, Amit G
David, Matei
Wilson, Nathan M
Dentro, Stefan
Wintersinger, Jeff J.A.
Liu, Leibao
Ko, Minjeong
Sivanandan, Srinivasan
Zhang, Hongjiu
Zhu, Kaiyi
Ou Yang, Tai-Hsien
Chilton, John JM
Buchanan, Alex
Lalansingh, Christopher CM
P'ng, Christine
Anghel, Catalina CV
Umar, Imaad
Lo, Bryan
Zou, William
DREAM SMC-Het Participants
Simpson, Jared T
Stuart, Joshua M
Anastassiou, Dimitris
Guan, Yuanfang
Ewing, Adam D
Ellrott, Kyle
Wedge, David C
Morris, Quaid
Van Loo, Peter
Boutros, Paul C

February 2020

Tumor DNA sequencing data can be interpreted by computational methods that analyze genomic heterogen...

Comparative Lesions Analysis Through a Targeted Sequencing Approach

VICENTINI, CARLO ALBERTO
Mafficini A.
Simbolo M.
Fassan M.
Delfino P.
Lawlor R. T.
Rusev B.
Scarpa A.
Corbo V.

January 2019

Assessing intra-tumoral heterogeneity (ITH) is of paramount importance to anticipate failure of targ...

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.

Andor, N.
Graham, T.A.
Jansen, M.A.
Xia, L.C.
Aktipis, C.A.
Petritsch, C.
Ji, H.P.
Maley, C.C.

January 2016

Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the...

Mutation, selection, and clonal expansion in tumor development leads to genomic heterogeneity between cells in a tumor.

Benjamin J. Raphael (44576)

December 2012

Current DNA sequencing approaches sequence DNA from many cells and thus result in a heterogenous ...

Homogeneity/Heterogeneity analysis of <i>FGFR1</i> amplified tumors.

Abstract

Extracted data

Homogeneity/Heterogeneity analysis of <i>FGFR1</i> amplified tumors.

Abstract

Extracted data

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