<p>Average IC<sub>50</sub> values for the activity of PN-2921 to inhibit IL-6-induced pSTAT3 signaling in U937 cells (n = 23), IL-6-induced inhibition of human whole blood monocytes (n = 6), and IL-6-induced proliferation in B9 cells (n = 3).</p><p>Summary of inhibitory Activity of PN-2921.</p
Image analysis was used to study the cytokine-inhibitory effect of the nitric oxide inhibitor tetrav...
1<p>Data presented are IC<sub>50</sub> values (µM) obtained using results summarized in <a href="htt...
This Article is brought to you for free and open access by the Biology at USF Scholarship Repository...
<p>In vitro potency of PN-2921 was determined by its ability to inhibit pSTAT3 signaling in Balb/c-3...
<p>(A) PB was stimulated with PGN (10 µg/ml) or LPS (1 µg/ml) and phospho-MAP kinases were measured ...
Signal transducer and activator of transcription factor 3 (STAT3) is hyperactivated in head and neck...
<p>Cynomolgus monkeys were treated SC with vehicle, and a second group of six male cynomolgus monkey...
<p>(A) Whole-cell lysates were prepared from the cells as indicated. -Actin was used as a control fo...
International audienceHuman IL6 is a cytokine produced by many cell types that has pleiotropic effec...
<p>(A) Inhibition of NO production in LPS-stimulated RAW264.7 cells, (B) Inhibition of mTNF-α produc...
<p>Balb/c mice were injected with either vehicle, the indicated dose of PN-2921, or a control anti-h...
Studies indicate that elevated interleukin-6 (IL-6) levels engage IL6Rα-gp130 receptor complexes to ...
<p>Cells were treated with inhibitor alone or co-incubated with poly-l-arginine (10 µM) in the prese...
<p>(A) Currents recorded when cells were perfused with divalent ion-free extracellular solution, IL-...
Human PBMCs were stimulated with recombinant (A) human or (B) cyno IL-21 in the presence of MEDI7169...
Image analysis was used to study the cytokine-inhibitory effect of the nitric oxide inhibitor tetrav...
1<p>Data presented are IC<sub>50</sub> values (µM) obtained using results summarized in <a href="htt...
This Article is brought to you for free and open access by the Biology at USF Scholarship Repository...
<p>In vitro potency of PN-2921 was determined by its ability to inhibit pSTAT3 signaling in Balb/c-3...
<p>(A) PB was stimulated with PGN (10 µg/ml) or LPS (1 µg/ml) and phospho-MAP kinases were measured ...
Signal transducer and activator of transcription factor 3 (STAT3) is hyperactivated in head and neck...
<p>Cynomolgus monkeys were treated SC with vehicle, and a second group of six male cynomolgus monkey...
<p>(A) Whole-cell lysates were prepared from the cells as indicated. -Actin was used as a control fo...
International audienceHuman IL6 is a cytokine produced by many cell types that has pleiotropic effec...
<p>(A) Inhibition of NO production in LPS-stimulated RAW264.7 cells, (B) Inhibition of mTNF-α produc...
<p>Balb/c mice were injected with either vehicle, the indicated dose of PN-2921, or a control anti-h...
Studies indicate that elevated interleukin-6 (IL-6) levels engage IL6Rα-gp130 receptor complexes to ...
<p>Cells were treated with inhibitor alone or co-incubated with poly-l-arginine (10 µM) in the prese...
<p>(A) Currents recorded when cells were perfused with divalent ion-free extracellular solution, IL-...
Human PBMCs were stimulated with recombinant (A) human or (B) cyno IL-21 in the presence of MEDI7169...
Image analysis was used to study the cytokine-inhibitory effect of the nitric oxide inhibitor tetrav...
1<p>Data presented are IC<sub>50</sub> values (µM) obtained using results summarized in <a href="htt...
This Article is brought to you for free and open access by the Biology at USF Scholarship Repository...