Distribution of MAFs of protein-altering mutations identified in cancer samples.

<p>Each boxplot shows the MAFs (from 0 to 1) of somatic SNVs found in an individual sample along with the mean (the red horizontal line), SEM (standard error of the mean, shown a blue box) and SD (standard deviation, shown as a blue vertical line). PDX samples (MAFs in blue dots) in general show higher mean MAF values (close to 0.5) than those from tumor samples (MAFs in green dots), which indicates that the PDX samples were of much higher tumor purity since reads from mouse stromal cells were effectively removed from the original sequencing data.