Drugs attenuated atherosclerotic lesion areas of aortic roots.

<p>Atherosclerosis was assessed using cross-sections (10 μm thick) of aortic roots from aortic sinuses to ascending aorta. (A) Representative tissue sections by Red Oil O staining used to assist in visualization of lesions in aortic roots. Left panel indicated the mice in control group (CTL), whereas right panel indicated the mice in ezetimibe group (EZE). (B) The distributions of atherosclerotic lesions from the aortic sinuses to ascending aorta between four groups. (C) Average lesion areas in the mice of four groups. Circles represent the values of individual mice, diamonds represent means, and bars are SEM. N = 9, 8, 11 and 11 for vehicle (Control), ezetimibe (EZE), atorvastatin (ATO), and combination (EZE+ATO) groups, respectively. Quantitative analysis of atherosclerosis was performed using Image-Pro software. Statistical analysis was performed using one way repeated measure ANOVA. * <i>P</i><0.001, compared with control group.