Muscle T2-rt, FA and K-trans evaluation after acute hindlimb ischemia.

<p>Representative T2-weighted images (<b>A</b>), FA maps (<b>D</b>) and K-trans maps (<b>G</b>) obtained at 1, 7 and 28 days after femoral artery dissection showing the heterogeneous involvement of the ischemic muscles and the modification of each parameter during the healing process. Time trend analysis of T2-rt, FA and K-trans are shown in panels B, C, E, F, H and I. Mean observed (circle: non-ischemic muscles; triangle: ischemic muscles) and model estimates (continuous line: non-ischemic muscles; broken line: ischemic muscles) are reported for the different time points. Vertical bars represents 95% confidence intervals according to the mixed regression model. Gas: Gastrocnemius muscle; TA: Tibialis anterior muscle. <b>B</b> and <b>C)</b> The graphs show the time trend analysis of T2-rt in Gastrocnemius and Tibialis anterior respectively, providing evidence for a different temporal trend between ischemic and non-ischemic muscles (interaction with time: Gastrocnemius p<0.01; Tibialis Anterior p<0.001). For non-ischemic muscles the temporal trend appeared constant. T2-rt levels were significantly increased at day 1 (both Gastrocnemius and Tibialis anterior p<0.001). <b>E)</b> and <b>F)</b> The graphs show the time trend analysis of FA in Gastrocnemius and Tibialis anterior respectively, providing evidence for a different non-linear temporal trend between ischemic and non-ischemic muscles (interaction with time p<0.001 for both Gastrocnemius and Tibialis anterior). For non-ischemic muscles the temporal trend were constant. FA levels were significantly decreased at day 1 (both Gastrocnemius and Tibialis anterior p<0.001) then started to converge. <b>H</b> and <b>I)</b> The graphs show the time trend analysis of K-trans in Gastrocnemius and Tibialis anterior respectively, providing evidence for a difference between ischemic and non-ischemic Tibialis anterior muscles (interaction with time, p<0.001). No evidence for a different temporal trend between ischemic and non-ischemic muscles was found for Gastrocnemius (p = 0.065). For Non Ischemic, muscles the temporal trend appeared constant. K-trans levels at day 1 were significantly decreased in Tibialis anterior (p = 0.002) then increased until day 28.