Mammary carcinoma cells with forced expression of TFF3 promoted tumor angiogenesis <i>in vivo</i>.

<p>(A) IHC analysis of CD31 and CD34 protein expressions in xenograft tumors formed by MCF-7 cells with forced expression of TFF3. (B) Microvessel density (CD31) was assessed by quantifying percentage area of CD31 labeled cells in xenografts formed by MCF-7 cells with forced expression of TFF3. (C) CD34 was assessed by quantifying percentage area of CD34 labeled cells in xenografts formed by MCF-7 cells with forced expression of TFF3. MCF-7 cells with empty vector (MCF7-Vec) used as control. **, <i>P</i> < <i>0</i>.<i>01</i>; ***, <i>P</i> < <i>0</i>.<i>001</i>; scale bar, 50 μm.