Results for simulated data.

<p>Means and standard deviations of 25 independent trials are given, and the curves displayed are for representative runs matching the 25-trial means. The true simulated rate is <i>μ</i> = 2.5 × 10⁻⁸ unless otherwise specified. (A) Baseline simulated data; the inferred rate is <i>μ</i> = 2.47 ± 0.05 × 10⁻⁸. (B) Basic simulated data with a true rate of 1.5 × 10⁻⁸; the inferred rate is <i>μ</i> = 1.57 ± 0.04 × 10⁻⁸. (C) Data with a true rate of 1.5 × 10⁻⁸ plus gene conversion; the inferred rate is <i>μ</i> = 1.49 ± 0.05 × 10⁻⁸ (corrected from a raw value of 1.70 × 10⁻⁸ with gene conversion included). (D) Data with simulated genotype errors; the inferred rate is <i>μ</i> = 2.39 ± 0.06 × 10⁻⁸ (corrected from a raw value of 2.71 × 10⁻⁸ with genotype errors included). (E) Data simulated with variable mutation rate; the inferred rate is <i>μ</i> = 2.61 ± 0.08 × 10⁻⁸. (F) Data from a simulated admixed population; the inferred rate is <i>μ</i> = 2.57 ± 0.07 × 10⁻⁸. (G) Simulated data with all three complications as in (D)–(F); the inferred rate is <i>μ</i> = 2.53 ± 0.06 × 10⁻⁸ (corrected from a raw value of 2.77 × 10⁻⁸).