Relationship of the canonical IL-17 pathway to the NF-κB-based network.

<p>Following activation of its receptor, IL-17 promotes transcription of many pro-inflammatory genes including CXCL1, CXCL5, CXCL6 and beta-defensin, indicated by the solid lines. (The networks were generated through the use of QIAGEN’s Ingenuity Pathway Analysis (IPA QIAGEN Redwood City, <a href="http://www.qiagen.com/ingenuity" target="_blank">www.qiagen.com/ingenuity</a>).