Odds ratio in multiple SNP-containing haplotypes in association with heroin dependence.

<p>Individual 2-, 3-, and 4-SNPs haplotypes, containing S1, S3, S5, and S29, significantly associated with heroin dependence (P < 0.05; P_{<i>Global</i>} < 0.05) are organized by their odds ratio (OR) in a descending order. Odd ratio of 1.00 serves as the baseline for determining haplotype risks. A blue square block represents the ancestral allele and a red square block represents the derived allele. An upward arrowhead in blue color shows risk-conferring effect of recombination and a downward arrowhead in green color shows protective effect of recombination. Neutral effect of recombination is represented by an upward arrowhead in white color. Dashed lines represent the cutoffs. Refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0142049#pone.0142049.s010" target="_blank">S8 Table</a> for further information on this figure. (A) Odds ratio of haplotypes in comparing overall heroin dependent (HER) and combined control (CON) groups (case n = 564; control n = 498). Odds ratio ≥ 4.73 is chosen as a cutoff for risk-conferring haplotypes to heroin dependence. Odds ratio ≤ 0.81 is chosen as a cutoff for protective haplotypes from heroin dependence. (B) Odds ratio of haplotypes in comparing pure heroin dependent subgroup and CON group (case n = 318; control n = 498). Odds ratio ≥ 3.55 is chosen as a cutoff for risk-conferring haplotypes to heroin dependence and OR ≤ 0.79 is chosen as a cutoff for protective haplotypes from heroin dependence. (C) Odds ratio of haplotypes in comparing multiple substance dependent subgroup and CON group (case n = 246; control n = 498). Odds ratio ≥ 5.72 is chosen as a cutoff for risk-conferring haplotypes to heroin dependence. Odds ratio ≤ 0.78 is chosen as a cutoff for protective haplotypes from heroin dependence.