<p>Curves represent the sigmoidal fittings of the data, obtained in triplicates, on PmV inhibition by either <b>Compound 1</b> (●) or WEHI916 (▲). Data were fluorescent readings from a single experiment, where both inhibitors were simultaneously analysed. Standard error bars (SEM) are included. In this experiment the calculated relative IC<sub>50</sub>s were 367 pM for <b>Compound 1</b> and 32.43 nM for WEHI916.</p
<p>(A) U373MG-EV, U373MG-PMLIII or U373MG-PMLIV cells were not infected (-) or infected with VSV at ...
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
<p>Enzyme activity in the presence of 100 μM compound (MMV# shown) was compared to activity of the e...
<p>IC<sub>50</sub> values, obtained in the presence of 3 μM of HRPII-PExEl substrate, are shown. The...
<p>The multiplex assay screened one compound (100 μM) against three enzymes. The activity of <i>Pf</...
<p>Representative examples of antiviral inhibition curves in a multiple cycle replication assay for ...
<p>Inhibition concentrations of Compound 29 and Chloroquine in strains producing different levels of...
<p>(A) Evaluation of anti-FMDV activity of 3Dpol inhibitors. Treatment with 15 µM of various compoun...
a<p>The required concentration to reduce 50% of plaque formation (EC<sub>50</sub>) was calculated by...
<p>IC<sub>50</sub>: half maximal inhibitory concentration. Values expressed in nM are presented as m...
<p>Structures for (A) UNC10112646 (B) UNC10225354 and (C) UNC10225498 (D) Dose-response curves for t...
<p>Points are experimentally determined values while solid lines are the computer-generated curves o...
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
<p>The inhibition observed at 40°C was taken as 100%. Each point represents the mean value ± SD of t...
<p>(A) A schematic illustration of a microliter-scale high-throughput screening system for three sam...
<p>(A) U373MG-EV, U373MG-PMLIII or U373MG-PMLIV cells were not infected (-) or infected with VSV at ...
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
<p>Enzyme activity in the presence of 100 μM compound (MMV# shown) was compared to activity of the e...
<p>IC<sub>50</sub> values, obtained in the presence of 3 μM of HRPII-PExEl substrate, are shown. The...
<p>The multiplex assay screened one compound (100 μM) against three enzymes. The activity of <i>Pf</...
<p>Representative examples of antiviral inhibition curves in a multiple cycle replication assay for ...
<p>Inhibition concentrations of Compound 29 and Chloroquine in strains producing different levels of...
<p>(A) Evaluation of anti-FMDV activity of 3Dpol inhibitors. Treatment with 15 µM of various compoun...
a<p>The required concentration to reduce 50% of plaque formation (EC<sub>50</sub>) was calculated by...
<p>IC<sub>50</sub>: half maximal inhibitory concentration. Values expressed in nM are presented as m...
<p>Structures for (A) UNC10112646 (B) UNC10225354 and (C) UNC10225498 (D) Dose-response curves for t...
<p>Points are experimentally determined values while solid lines are the computer-generated curves o...
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
<p>The inhibition observed at 40°C was taken as 100%. Each point represents the mean value ± SD of t...
<p>(A) A schematic illustration of a microliter-scale high-throughput screening system for three sam...
<p>(A) U373MG-EV, U373MG-PMLIII or U373MG-PMLIV cells were not infected (-) or infected with VSV at ...
<p>The IC<sub>50</sub> values are given in nM. Values and errors (SE) shown are representative of n ...
<p>Enzyme activity in the presence of 100 μM compound (MMV# shown) was compared to activity of the e...