Partial nephrectomy and adenine-enriched dietary treatment induced CKD.

<p>Mice subjected to <b>(A)</b> partial nephrectomy (5/6Nx; n = 9) after 3 weeks and <b>(B)</b> adenine-enriched dietary treatment (ADE; n = 5) for either 2 or 4 weeks display elevated blood urea levels, when compared to sham-operated (n = 5) or control mice (n = 5), respectively. Renal expression of tubular injury marker NGAL is significantly elevated in <b>(C)</b> 5/6Nx mice and <b>(D)</b> ADE mice after 2 and 4 weeks, compared to sham-operated or control mice, respectively. Data are mean ± SEM. *: p<0.05 compared to either sham-operated or control mice.