Thrombin (FIIa; A) and APC (B) generation, and TM (C, D), EPCR (E, F), and Protein S (G, H) expression, on the endocardial surface of wildtype, all HF (HF), early HF, acute HF, and chronic HF mice.

<p>Thrombin generation is increased in acute HF compared to wildtype mice (A). APC generation is decreased in all HF mice compared to wildtype mice (B). TM (C) and EPCR (E) <u>mRNA</u> expression is attenuated in all HF mice groups compared to wildtype mice. Protein S (G) transcripts are also decreased in early and chronic HF mice. <u>Protein</u> expression of TM (D) and Protein S (H) is decreased in chronic HF compared to wildtype mice. EPCR (F) protein expression is attenuated in early and acute HF mice relative to wildtype and chronic HF mice. *p<0.05, **p<0.01, ***p<0.005.