Single cytokine CD4 and CD8 T-cell responses to vaccine antigens.

<p>The magnitude of CD4 (A) and CD8 (B) T-cell IFN-γ, IL-2, TNF-α or any cytokine (Any) responses following short term stimulation with PPD in HIV-unexposed (HU) and HIV-exposed uninfected (HEU) infants in month 3 (M3) and month 12 (M12) age groups. Similarly, the magnitude of cytokine responses to TT are shown in (C) for CD4 T-cells only. The horizontal black line is the median frequency of T-cells expressing the indicated cytokine or any cytokine. The Mann Whitney U test was used to assess differences between the two groups.