Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways - Fig 4

<p><b>Overall structure of AQP5 S156E.</b> (A) The structure of full length (green, PDB code 4DYE) and truncated S156E AQP5 (orange, PDB code 5CX6) overlaid on the wild-type structure of AQP5 in blue (PDB code 3D9S). Water molecules in the water-conducting channel of truncated S156E AQP5 are shown as red spheres. (B) Same as in (A), viewed from the cytoplasmic side. (C) Structure of the carboxy-terminus of full-length S156E monomer D, showing its interactions with a symmetry-related molecule (grey). 2F_obs-F_calc electron density is displayed at 1.0 σ. Loop D and Glu 156 in monomers A and D are highlighted in yellow. (D) Lipid molecule in the tetrameric channel of full-length and truncated AQP5 S156E.