The granzyme A/K locus.

<p>The genes encoding serine proteases are depicted in double height to easily locate them in the maps. The bordering genes are included to easily trace the origin of the locus and to also define changes that have occurred upstream or downstream of the locus. Gene names in the database as A or K in fish and amphibians do not always match their closest homologs in mammals. The granzyme A and K genes from mammals, birds and reptiles form distinct sub-branches and are therefore depicted in dark and light blue respectively. The color coding in fish is not so distinct but the genes have been coded light and dark blue as named in the database. However, as seen in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0143091#pone.0143091.g006" target="_blank">Fig 6E</a>, they cluster together and not within the mammalian sub-branches for A and K. Three genes of the cichlid GzmA/Ks that have specificity triplets as the chymases, SGG, have been marked by red stars.