Increased HCC tumorigenesis in DEN-treated <i>Arid1a</i>^<i>LKO</i> mice (A).

<p>A brief scheme illustrating DEN-induced HCC experiments in <i>Arid1a</i>^<i>LKO</i> mice and <i>Arid1a</i>^<i>f/f</i> littermates. (B). Representative macroscopic livers from 9 month old male <i>Arid1a</i>^<i>f/f</i> (left) and <i>Arid1a</i>^<i>LKO</i> mice (right). Multiple larger tumor nodules on the surface of the livers of <i>Arid1a</i>^<i>LKO</i> mice are shown. (C). Tumor nodules were counted and statistically analyzed using an unpaired two-sample Student’s <i>t</i>-test. The data are shown as the means ± SEM. The <i>P</i> value is shown above compared groups. (D-F). Serum ALT (D), IL-6 (E) and TNF-α (F) levels in 4 month old <i>Arid1a</i>^<i>LKO</i> and <i>Arid1a</i>^<i>f/f</i> mice. Each spot represents the measured value from each individual of two genotype groups, where each group contains a minimum of 5 individuals. The data are shown as the means ± SEM. Statistical analysis was performed using an unpaired two-sample Student’s <i>t</i>-test. <i>P</i> values are shown above compared groups.