Additional file 4: Figure S3. of Upregulation of EGFR signaling is correlated with tumor stroma remodeling and tumor recurrence in FGFR1-driven breast cancer

Tumors recur much faster in the third recurrence as compared to the first and second recurrences. A. Scheme for BGJ398 treatment and tumor recurrence (third recurrence). B. Timing of tumor regression and recurrence for individual Wnt1/iR1 tumors. C. Comparison of the recurrence latency between the first, the second and the third recurrences. Latency is calculated from the day of BGJ398 withdrawal to the day when the recurrent tumors reached 100 mm3 (n = 3); **p < 0.001. (TIF 21045 kb