<div><p></p><p>The conversion of a wide range of primary and secondary aliphatic and a few arylamine hydrochloride salts to their corresponding acetamides with trimethyl orthoacetate is described. Mechanistic studies using NMR and gas chromatography–mass spectrometry techniques indicate these reactions proceed via an <i>O</i>-methylimidate intermediate that undergoes in situ demethylation by chloride, affording the corresponding acetamides. Synthetically, this reaction represents a practical, high-yielding protocol with a simple workup for the rapid conversion of amine hydrochloride salts to acetamides.</p></div
Current methods for constructing amide bonds join amines and carboxylic acids by dehydrative couplin...
A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and...
The reaction of a lactone or an ester with organoaluminum species generated from DIBAL-H-H2NR or DIB...
An examination has been made of direct procedures for the synthesis of amides. Dodecylamine, tetrade...
Despite the amide formation reaction being a key reaction in organic chemistry, the direct amide for...
A general method for the synthesis of amides involving the direct coupling of alkali metal carboxyla...
These reactions can be carried out directly on aromatic amines (initial in situ acetanilide formati...
AbstractThe treatment of aryl amines with dimethylformamide (DMF) and dimethylacetamide (DMA) in the...
Some aliphatic carboxylic anhydrides gave excellent yields of the novel addition products to both al...
Investigating the methylation of amides 1 (Scheme 1) which were derived from -aminobutyric acid we o...
Despite the amide formation reaction being a key reaction in organic chemistry, the direct amide for...
A TiCl4-mediated reaction for the direct amination of alpha-hydroxy amides has been developed. This ...
A practical method for the amidation of aldehydes with economic ammonium chloride or amine hydrochlo...
International audienceThe amide functionality is one of the most important and widely used groups in...
Chlorination of amides is of utmost importance in biochemistry and environmental chemistry. Despite ...
Current methods for constructing amide bonds join amines and carboxylic acids by dehydrative couplin...
A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and...
The reaction of a lactone or an ester with organoaluminum species generated from DIBAL-H-H2NR or DIB...
An examination has been made of direct procedures for the synthesis of amides. Dodecylamine, tetrade...
Despite the amide formation reaction being a key reaction in organic chemistry, the direct amide for...
A general method for the synthesis of amides involving the direct coupling of alkali metal carboxyla...
These reactions can be carried out directly on aromatic amines (initial in situ acetanilide formati...
AbstractThe treatment of aryl amines with dimethylformamide (DMF) and dimethylacetamide (DMA) in the...
Some aliphatic carboxylic anhydrides gave excellent yields of the novel addition products to both al...
Investigating the methylation of amides 1 (Scheme 1) which were derived from -aminobutyric acid we o...
Despite the amide formation reaction being a key reaction in organic chemistry, the direct amide for...
A TiCl4-mediated reaction for the direct amination of alpha-hydroxy amides has been developed. This ...
A practical method for the amidation of aldehydes with economic ammonium chloride or amine hydrochlo...
International audienceThe amide functionality is one of the most important and widely used groups in...
Chlorination of amides is of utmost importance in biochemistry and environmental chemistry. Despite ...
Current methods for constructing amide bonds join amines and carboxylic acids by dehydrative couplin...
A practical route to tertiary diarylmethylamides or -carbamates from imines, organozinc reagents and...
The reaction of a lactone or an ester with organoaluminum species generated from DIBAL-H-H2NR or DIB...