A schematic representation of GPVI signal transduction in a platelet.

<p>GPVI is present as a complex associated with Fc receptor (FcR) γ-chain and Src family kinases (SFK) that phosphorylate an immunoreceptor tyrosine based activation motif (ITAM) in the FcR γ-chain. This allows recruitment and activation of the cytosolic tyrosine kinase Syk that leads to phosphorylation of adaptor proteins such as LAT (linker for Activation of T-cells), PI3K (phosphoinositide 3-kinase) and ultimately activation of PLCγ2 (phospholipase C). These molecules participate in triggering the downstream processes of calcium release, shape change and granule secretion that all form part of platelet activation. Arrows are not intended to imply direct phosphorylation or activation.