Ablation of β-catenin in DCs resulted in elevated total CD4⁺ T-cell numbers under steady state condition.

<p>The left panels depict representative FACS plots of CD8⁺, TCRγδ⁺, CD4⁺, CD4⁺CCR6^- and CD4⁺CCR6⁺, Th17 or Th17.1 and Th2 or Th1 T cells isolated from the spleens of control and β-cat^DEL mice under steady state condition. The right panels illustrate the quantification of the percentages of CD8⁺, TCRγδ⁺, CD4⁺, Tfh (CXCR5⁺PD-1⁺), CD4⁺CCR6⁺ and CD4⁺CCR6^- T cells, expressed in frequency of total T cells (CD3⁺); the frequency of NK T cells (NK1.1⁺) is expressed in percentage of CD3^- cells. The percentages of Th cells were expressed in frequency of effector T-cells (CD3⁺CD4⁺CD62L^-). N = 6 mice per group. Data are presented as mean + SEM. Asterisks indicate a significant difference compared with the control (Mann-Whitney <i>U</i> test). <i>*p< 0</i>.<i>05</i>.