tau phosphorylation at the AT8 epitope was not significantly altered in L-methionine mice. A) Histologically fixed 30-μm slices from control and L-methionine mice brains were analyzed by immunocytochemistry to analyze the presence of AT8-positive cells that detect tau phosphorylation at Thr205. (Left) Cortex and hippocampus sections of control mice;(right) L-methionine brain sections, both at 20x. B) Quantification of the photographs did not show any significant difference on this epitope of tau phosphorylation between treated and control mouse tissues. (TIFF 533 kb
The effects of IGFBP-3 on the phosphorylation of tau (AT180). To confirm the effect of IGFBP-3 on ph...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Additional file 1: Fig. S1. Generation and genomic identification of hTau368 mice. Fig. S2. hTau368 ...
Levels of lipids and hepatic enzime profile in mice treated with L-methionine rich diet. (TIFF 85 kb
Water consumption and body weight are not affected by a high-L-methionine diet. A) Water intake was ...
Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...
Figure S1. Western blot results of tau expression in mice expressing pro- or anti-aggregant human ta...
T5x mice exhibit increased levels of Tau phosphorylation and misfolding. (A) The ratio of phosphoryl...
Figure S2. Correlation between miRNA expression and pathology load in APPtg and TAUtg mice and AD pa...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
AAV-PS1 and AAV-APP mice do not exhibit neuronal defects in terms of PSD-95, GLT-1 and tonic glutama...
Figure S1. Accumulation of soluble, hyperphosphorylated tau in A152T-expressing mice. Figure S2. Inc...
Figure S3. LDclns exacerbated the accumulation of tau and PHF-1 in A53T mice. a Representative bands...
Brain levels of the β-site of APP cleaving enzyme (BACE-1) mRNA. Expression levels of mRNA were norm...
Figure S1. Doxycycline-inducible cell line expressing human mutant P301L tau. Western blot of cell l...
The effects of IGFBP-3 on the phosphorylation of tau (AT180). To confirm the effect of IGFBP-3 on ph...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Additional file 1: Fig. S1. Generation and genomic identification of hTau368 mice. Fig. S2. hTau368 ...
Levels of lipids and hepatic enzime profile in mice treated with L-methionine rich diet. (TIFF 85 kb
Water consumption and body weight are not affected by a high-L-methionine diet. A) Water intake was ...
Western blot analysis of A brain-derived neurotrophic factor (BDNF), B Growth associated protein 43 ...
Figure S1. Western blot results of tau expression in mice expressing pro- or anti-aggregant human ta...
T5x mice exhibit increased levels of Tau phosphorylation and misfolding. (A) The ratio of phosphoryl...
Figure S2. Correlation between miRNA expression and pathology load in APPtg and TAUtg mice and AD pa...
Figure S3. HFD affects clearance of ISF Aβ. a, b The expression of APP, CTFα/β, BACE1 ADAM10 and α–t...
AAV-PS1 and AAV-APP mice do not exhibit neuronal defects in terms of PSD-95, GLT-1 and tonic glutama...
Figure S1. Accumulation of soluble, hyperphosphorylated tau in A152T-expressing mice. Figure S2. Inc...
Figure S3. LDclns exacerbated the accumulation of tau and PHF-1 in A53T mice. a Representative bands...
Brain levels of the β-site of APP cleaving enzyme (BACE-1) mRNA. Expression levels of mRNA were norm...
Figure S1. Doxycycline-inducible cell line expressing human mutant P301L tau. Western blot of cell l...
The effects of IGFBP-3 on the phosphorylation of tau (AT180). To confirm the effect of IGFBP-3 on ph...
FigureS2. Unlike STAT3, STAT1 and Erk are not activated in APP astrocytes. Confocal images of staine...
Additional file 1: Fig. S1. Generation and genomic identification of hTau368 mice. Fig. S2. hTau368 ...