Effects of neonatal whisker trimming on the topographic organization of the adult barrel field and on unimodal evoked responses in S1 and V1.

<p>(<b>A</b>) Flattened histological sections including the posteromedial barrel field of the S1 stained for COX from a CON (top) and a NWT (bottom) rat. Barrel rows and columns are marked with letters and numbers. (<b>B</b>) Bar diagram displaying the size of individual barrels averaged for seven CON and seven NWT rats. (<b>C</b>) Averaged tactile potentials evoked by contralateral whisker deflection in S1 of CON (black traces) and NWT (gray traces) rats displayed together with the corresponding color-coded current source density (CSD) depth profile from CON rats. Numbers to the left mark the recording sites of the multielectrode array positioned in supragranular, granular and infragranular layers. For the evoked potential (EP) recorded in one channel in the granular layer the first three peaks (P1, N1, P2) are marked. (<b>D</b>) Averaged visual potentials evoked by contralateral light flashes in S1 of CON (black traces) and NWT (gray traces) rats displayed together with the corresponding color-coded CSD depth profile from CON rats. (<b>E</b>) Averaged visual potentials in V1 of CON (black traces) and NWT (gray traces) rats displayed together with the corresponding color-coded CSD depth profile from CON rats. (<b>F</b>) Bar diagrams displaying the mean amplitude of P1 (left), N1 (middle), and P2 (right) after tactile stimulation in supragranular (top), granular (middle) and infragranular (bottom) layers of the S1 in CON and NWT rats. (<b>G</b>) Same as (F) for visual stimulation and recordings in S1. (<b>H</b>) Same as (G) for visual stimulation and recordings in V1. The underlying data of this figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002304#pbio.1002304.s001" target="_blank">S1 Data</a>. <a href="http://dx.doi.org/10.6084/m9.figshare.1540797" target="_blank">http://dx.doi.org/10.6084/m9.figshare.1540797</a>