Hydroxylated <i>Daphniphyllum</i> Alkaloids from <i>Daphniphyllum himalense</i>

Thirteen new hydroxylated calyciphylline A-type <i>Daphniphyllum</i> alkaloids (<b>1</b>–<b>13</b>) were isolated from an ethanolic extract of <i>Daphniphyllum himalense</i>. These structures were characterized on the basis of spectroscopic data analysis, especially from their 2D NMR spectra. Oxidation at the C-3, C-9, C-11, and C-12 positions is reported for the first time for this class of compounds. Selective compounds showed low inhibitory rates against three kinase enzymes, PTP1B, aurora A, and IKK-β, at a concentration of 20 μg/mL