<p>Brains sections were stained with Thioflavine-S and plaques were counted in the whole section. The ratio of plaques/slice is plotted. WT Ctrl (n = 4) did not present any plaques. Treatment with lithium during 16 months reduced the number of plaques in TG Li16 (n = 5) compared to TG Ctrl (n = 6). TG Li8 (n = 5) also presented a reduction but it was not statistically different. Data were plotted in median and interquartile range. *: P < 0.01.</p
AbstractThe deposition of β-amyloid peptide (Aβ), the hyperphosphorylation of tau protein and the de...
Lithium is an anti-psychotic that has been shown to prevent the hyperphosphorylation of tau protein ...
<p>(A) Pre-treatment of lithium 1 h before TMT treatment (5 µM) significantly inhibited LDH release ...
<p>A–D: immunohistochemical detection of Aβ plaques in the cortex (A,B) and hippocampus (C,D) of sal...
<p>A–D representative photomicrographs of Aβ (1–42) immunolabelled amyloid plaques in the cortex (A,...
<p>(A) Bar graphs in the left panel show that lithium administration significantly reduced the densi...
Lithium is an anti-psychotic that has been shown to prevent the hyperphosphorylation of tau protein ...
<div><p>The use of lithium is well established in bipolar disorders and the benefits are being demon...
<p>Panels A–F show Nissl staining for wildtype (A and D), APPSwDI/NOS2−/− mice receiving control die...
<p>MPS IIIB (−/−) or control (+/−) mice were provided with LiCl in their chow, 3 g/kg, or fed regula...
<p>Panel A shows representative Western blot images for AT8, AT180 and ß-actin for APPSwDI/NOS2−/− m...
<p>Brain homogenates were tested to BDNF by ELISA. There was no difference in BDNF levels either in ...
Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, in...
Abstract Background Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extrac...
<p>Panels A and B show biochemical ELISA measurement of Aβ38, 40 and 42 in soluble (A) and insoluble...
AbstractThe deposition of β-amyloid peptide (Aβ), the hyperphosphorylation of tau protein and the de...
Lithium is an anti-psychotic that has been shown to prevent the hyperphosphorylation of tau protein ...
<p>(A) Pre-treatment of lithium 1 h before TMT treatment (5 µM) significantly inhibited LDH release ...
<p>A–D: immunohistochemical detection of Aβ plaques in the cortex (A,B) and hippocampus (C,D) of sal...
<p>A–D representative photomicrographs of Aβ (1–42) immunolabelled amyloid plaques in the cortex (A,...
<p>(A) Bar graphs in the left panel show that lithium administration significantly reduced the densi...
Lithium is an anti-psychotic that has been shown to prevent the hyperphosphorylation of tau protein ...
<div><p>The use of lithium is well established in bipolar disorders and the benefits are being demon...
<p>Panels A–F show Nissl staining for wildtype (A and D), APPSwDI/NOS2−/− mice receiving control die...
<p>MPS IIIB (−/−) or control (+/−) mice were provided with LiCl in their chow, 3 g/kg, or fed regula...
<p>Panel A shows representative Western blot images for AT8, AT180 and ß-actin for APPSwDI/NOS2−/− m...
<p>Brain homogenates were tested to BDNF by ELISA. There was no difference in BDNF levels either in ...
Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, in...
Abstract Background Alzheimer’s disease (AD) is characterized by the abnormal accumulation of extrac...
<p>Panels A and B show biochemical ELISA measurement of Aβ38, 40 and 42 in soluble (A) and insoluble...
AbstractThe deposition of β-amyloid peptide (Aβ), the hyperphosphorylation of tau protein and the de...
Lithium is an anti-psychotic that has been shown to prevent the hyperphosphorylation of tau protein ...
<p>(A) Pre-treatment of lithium 1 h before TMT treatment (5 µM) significantly inhibited LDH release ...