mRNA levels in kidneys of LETO and OLETF rats.

<p>The mRNA levels in kidneys of LETO and OLETF rats, 12 weeks after the start of Paigen diet feeding, are presented as mean ± SD. There were five animals in the group of LETO rats fed normal chow (LETO-NC), eight in the group of OLETF rats fed normal chow (OLETF-NC), and 12 in the group of OLETF rats fed a Paigen diet (OLETF-PD). #p < 0.05; ##p < 0.01; NS, not significant by unpaired t-test. Col4a1, procollagen type IV 4α; Gpx2, glutathione peroxidase 2; HIF-1α, hypoxia inducible factor 1α; HO-1, heme oxygenase 1; IL-1β, interleukin-1β; KIM-1, kidney injury molecule-1; MCP-1, monocyte chemoattractant protein-1; MRP8, myeloid-related protein 8; NOX2, NADPH oxidase 2; NOX4, NADPH oxidase 4; TGF-β, transforming growth factor-β; TLR4, toll-like receptor 4; TNF-α, tumor necrosis factor-α; VCAM-1, vascular cell adhesion molecule-1.