The Mice Transplanted with Bone Marrow Cells Transduced with <i>MYC</i>-deleted Retroviral cDNA Library Developed Acute Myeloid Leukemia Harboring <i>MEIS1</i> and One of Four <i>HOX</i> cDNA Inserts.

<p>The leukemic cells from the 8 mice that have developed leukemia were analyzed in terms of their surface phenotype and cDNA inserts. The bone marrow cells were transduced with the retroviral cDNA library supernatant on Day 1 and again on Day 2. One million retrovirus-transduced bone marrow cells were transplanted into 9 irradiated host mice. One mouse died at Day 7 with unknown cause and was excluded from the analysis. <b>A</b>. Mouse 2–3 (<i>MEIS1</i> + <i>HOXA6</i>), <b>B</b>. Mouse 2–10 (<i>MEIS1</i> + <i>HOXB6</i>), <b>C</b>. Mouse 2–9 (<i>MEIS1</i> + <i>HOXB7</i>). <b>D</b>. Mouse 2–6 (<i>MEIS1</i> + <i>HOXD8</i>).