Changes in gene expression related to foam cell formation in the macrophages obtained from <i>Apoe</i>^{<i>−/−</i>} mice.

<p>Gene expressions were measured in the peritoneal macrophages obtained from non-diabetic <i>Apoe</i>^{<i>−/−</i>} mice (n = 7), diabetic <i>Apoe</i>^{<i>−/−</i>} mice that received vehicle (n = 6), and those that received dapagliflozin (n = 5). Gene expressions of (A) lectin-like ox-LDL receptor-1 (Lox-1), (B) CD36, (C) acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1), (D) ATP-binding cassette transporter A1 (ABCA1), and (E) ATP-binding cassette sub-family G member1 (ABCG1) and the association with GAPDH were analyzed by real-time RT-PCR before the addition of ox-LDL. The values show mean ± SEM. One-way ANOVA followed by Tukey test for the comparison of <i>Apoe</i>^{<i>−/−</i>} mice: *<i>p</i> < 0.05, ^†<i>p</i> < 0.01.