CD8 T cell activation occurred during the incubation period, although not an EBV specific response.

<p>(A), Time to first response for three distinct immune parameters is shown: CD38 upregulation on total CD8⁺ T cells (filled squares), an increased CD8 to CD4 T cell ratio (open diamonds), or the presence of EBV tetramer binding CD8⁺ T cells above background (0.4%) (filled circles). (B) Frequency of CD8⁺ T cells expressing CD38 over time. (C) Ratio of CD8⁺ to CD4⁺ T cells over time. Statistics were performed using a one-way ANOVA with multiple test comparison. Pink symbols indicate a significant difference (p<0.05) compared to pre-infection. Red symbols indicate a significant difference (p<0.0001) compared to pre-infection. Gray symbols indicate no statistical difference.