<p>The comparison was performed with the full-length EV68 VP1 region (306 amino acids) from 117 EVD68 sequences. The clade classification is shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0144208#pone.0144208.g001" target="_blank">Fig 1</a>. Values in the lower-left indicate the average number of different amino acids between the clades, with the range in parentheses. Values in the upper-right indicate the relative percentage of the VP1 region that differs among the clades. Sequence alignment and calculation were performed using MEGA5 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0144208#pone.0144208.ref036" target="_blank">36</a>].</p><p>Amino acid variation in the VP1 residues of di...
<p>The region of <i>env</i> gene coding for the surface glycoprotein, gp90, of the Env variants, EV0...
<p>VP1 amino acid sequences of GII.17 from the study area were aligned with former related sequences...
The factors that determine the relative rates of amino acid substitution during protein evolution ar...
<p>In total, there were 297 amino acids in the VP1 protein of EV71, and 26 residue variations were f...
<p><b>(A)</b> VP1 protein alignment based on the Clade B subcluster. The alignment was performed wit...
Alignment of VP1 amino acids sequence of Egyptian strains and reference strains shows several points...
Alignment of VP1 amino acids sequence of Egyptian strains and reference strains shows several points...
<p>The percentage in 1702 sequences is shown in parentheses.</p>1)<p>Not determined as there was a m...
Alignment of VP1 amino acids sequence of Egyptian strains and reference strains shows several points...
Sequences in this study (green closed square) are named as mentioned in the main text. Sequences fro...
<p>Substitution rates of individual aligned amino acid positions can differ between clades of orthol...
<p>Partial alignment of the VP3 protein sequences of EV71 strains from representative subgenogroups,...
<div><p>The 1000 Genomes Project data provides a natural background dataset for amino acid germline ...
The 1000 Genomes Project data provides a natural background dataset for amino acid germline mutation...
Phylogenomic analyses of ancient relationships are usually performed using amino acid data, but it i...
<p>The region of <i>env</i> gene coding for the surface glycoprotein, gp90, of the Env variants, EV0...
<p>VP1 amino acid sequences of GII.17 from the study area were aligned with former related sequences...
The factors that determine the relative rates of amino acid substitution during protein evolution ar...
<p>In total, there were 297 amino acids in the VP1 protein of EV71, and 26 residue variations were f...
<p><b>(A)</b> VP1 protein alignment based on the Clade B subcluster. The alignment was performed wit...
Alignment of VP1 amino acids sequence of Egyptian strains and reference strains shows several points...
Alignment of VP1 amino acids sequence of Egyptian strains and reference strains shows several points...
<p>The percentage in 1702 sequences is shown in parentheses.</p>1)<p>Not determined as there was a m...
Alignment of VP1 amino acids sequence of Egyptian strains and reference strains shows several points...
Sequences in this study (green closed square) are named as mentioned in the main text. Sequences fro...
<p>Substitution rates of individual aligned amino acid positions can differ between clades of orthol...
<p>Partial alignment of the VP3 protein sequences of EV71 strains from representative subgenogroups,...
<div><p>The 1000 Genomes Project data provides a natural background dataset for amino acid germline ...
The 1000 Genomes Project data provides a natural background dataset for amino acid germline mutation...
Phylogenomic analyses of ancient relationships are usually performed using amino acid data, but it i...
<p>The region of <i>env</i> gene coding for the surface glycoprotein, gp90, of the Env variants, EV0...
<p>VP1 amino acid sequences of GII.17 from the study area were aligned with former related sequences...
The factors that determine the relative rates of amino acid substitution during protein evolution ar...