Evogliptin increased energy expenditure unlike exenatide.

<p>HF-DIO mice were treated with exenatide (30 μg kg^-1, once daily, s.c.) or evogliptin at 0.081% (w/w) for 2 weeks. Metabolic parameters were measured using an indirect calorimetry system; (A) Oxygen consumption (VO₂) and carbon dioxide production (VCO₂), (B) mean energy expenditure (EE), (C) respiratory quotient (Rq), and (D) a plot of individual data of total mean EE vs. (lean mass + 0.2 × fat mass) as a covariate (n = 8/group). #, <i>P</i> < 0.05 vs. lean control and *, <i>P</i> < 0.05 vs. HF-DIO control by one-way ANOVA.