Early infection of Tfh cells.

<p>(A) Frequencies of SIV DNA and (B) RNA in sorted Tfh and effector memory CD4 T cells isolated from LNs and spleen of RMs infected with SIV. Each dot represents an individual RM. Statistical analyses are performed using Mann Whitney test. *, p<0.05; **, p<0.01. At day>180, open circles represent fast progressor RMs, PB023 and PB028; and full diamonds represent slow progressor RMs, PB013 and PB044. (C) Correlation between the frequencies of SIV DNA⁺ Tfh cells and the percentage of B cell subsets (as defined in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1005287#ppat.1005287.g005" target="_blank">Fig 5</a>) in LNs and spleen of RMs. Each dot represents an individual macaque. Spearman analysis was used for correlations.