Connectivity, node placement and how this relates to the mathematical model.

<p>Connectivity is shown where connections exist in 60% or more of subjects, for visualisation only—all connections were included on a subject specific basis for simulations. Nodes and connections are overlaid on a 3D brain image to show the rough positioning of the nodes and the distance of connections between them. The nodes are the positions of ROI, with colours corresponding to different lobes, and the black lines show the connections between different regions. The zoomed in top left graphic shows how connections between nodes are weighted, and the blue box shows how the activity change of one node is found using the model. The bottom right figure shows a time series of the model simulation. The model begins in the background state with low amplitude oscillations and transits to a high amplitude seizure-like state at approximately t = 14, indicated by the dashed line. In this exemplary case the escape time would be taken as 14 for the node in this simulation.