Proton Radiation Results in rPVT Deficits in F344 Rats.

<p>Mean rPVT performance across 34 weeks post-irradiation in F344 and LEW rats (n = 4–8 rats/group). Accuracy (percent correct) for 25 cGy-exposed (A) or 100 cGy-exposed (B) F344 and LEW rats; sham controls appear on all panels. Impulsivity (false alarm rate) for 25 cGy-exposed (C) or 100 cGY-exposed (D) F344 and LEW rats; median reaction time for 25 cGy-exposed (E) or 100 cGy-exposed (F) F344 or LEW rats. *denotes significant difference from F344 sham control, other details appear in the text. BL = baseline rPVT performance for each group the week prior to irradiation.