Centrins are calcium binding proteins that belong to the EF-hand superfamily with diverse biological functions. Herein we present the first systematic study that establishes the relative stability of related centrins via complementary biophysical techniques. Our results define the stepwise molecular behavior of human centrins by two-dimensional infrared (2D IR) correlation spectroscopy, the change in heat capacity and enthalpy of denaturation by differential scanning calorimetry, and the relative stability of the helical regions of centrins by circular dichroism. More importantly, 2D IR correlation spectroscopy provides unique information about the similarities and differences in dynamics between these related proteins. The thermally induce...
Centrin2 is a centrosomal calcium-binding protein that plays a critical role in centriole dynamics a...
*S Supporting Information ABSTRACT: Insight into structural and motional features of the C-terminal ...
AbstractCentrins are members of the EF-hand family of calcium-binding proteins, which are highly con...
Centrins are calcium-binding proteins associated with microtubules organizing centers. Members of tw...
AbstractCentrins are calcium-binding proteins associated with microtubules organizing centers. Membe...
Centrin, an EF-hand calcium-binding protein, has been shown to be involved in the duplication of cen...
Centrin, an EF-hand calcium-binding protein, has been shown to be involved in the duplication of cen...
We analyzed the metal-binding properties of human centrin-2 (HsCen-2) and followed the changes in Hs...
AbstractCentrin and calmodulin (CaM) are closely related four-EF-hand Ca2+-binding proteins. While C...
International audienceHuman centrin 2 (HsCen2), an EF-hand calcium binding protein, plays a regulato...
Centrins are calcium-binding proteins that can interact with several cellular targets (Sfi1, XPC, Sa...
International audienceBACKGROUND: Disrupting protein-protein interactions by small organic molecules...
AbstractCentrins are members of the family of Ca2+-binding EF-hand proteins. In photoreceptor cells,...
Using optical spectroscopy, nuclear magnetic resonance (NMR), and differential scanning Calorimetry ...
Centrins are acidic proteins, present in all eukaryotes to perform imperative roles in centrosome po...
Centrin2 is a centrosomal calcium-binding protein that plays a critical role in centriole dynamics a...
*S Supporting Information ABSTRACT: Insight into structural and motional features of the C-terminal ...
AbstractCentrins are members of the EF-hand family of calcium-binding proteins, which are highly con...
Centrins are calcium-binding proteins associated with microtubules organizing centers. Members of tw...
AbstractCentrins are calcium-binding proteins associated with microtubules organizing centers. Membe...
Centrin, an EF-hand calcium-binding protein, has been shown to be involved in the duplication of cen...
Centrin, an EF-hand calcium-binding protein, has been shown to be involved in the duplication of cen...
We analyzed the metal-binding properties of human centrin-2 (HsCen-2) and followed the changes in Hs...
AbstractCentrin and calmodulin (CaM) are closely related four-EF-hand Ca2+-binding proteins. While C...
International audienceHuman centrin 2 (HsCen2), an EF-hand calcium binding protein, plays a regulato...
Centrins are calcium-binding proteins that can interact with several cellular targets (Sfi1, XPC, Sa...
International audienceBACKGROUND: Disrupting protein-protein interactions by small organic molecules...
AbstractCentrins are members of the family of Ca2+-binding EF-hand proteins. In photoreceptor cells,...
Using optical spectroscopy, nuclear magnetic resonance (NMR), and differential scanning Calorimetry ...
Centrins are acidic proteins, present in all eukaryotes to perform imperative roles in centrosome po...
Centrin2 is a centrosomal calcium-binding protein that plays a critical role in centriole dynamics a...
*S Supporting Information ABSTRACT: Insight into structural and motional features of the C-terminal ...
AbstractCentrins are members of the EF-hand family of calcium-binding proteins, which are highly con...