Influenza A virus infection causes a contagious respiratory illness that poses a threat to human health. However, there are limited anti-influenza A therapeutics available, which is further compounded by the emergence of drug resistant viruses. In this study, Sophora quinolizidine alkaloids were identified as a new class of anti-influenza A virus agents. Among the tested Sophora alkaloids, dihydroaloperine exhibited the most potent activity with an EC<sub>50</sub> of 11.2 μM. The potency of the quinolizidine alkaloids was improved by approximately 5-fold with chemical modifications on the aloperine molecule. These compounds were effective against an H1N1 influenza A virus that was resistant to the two antiflu drugs oseltamivir and amantadin...
To investigate the influence of the variation of the original skeletons of natural phenanthroindo/qu...
<div><p>A series of phenanthroquinolizidine alkaloids <b>1</b>–<b>24</b> were prepared and first eva...
Influenza virus is the main cause of an infectious disease called influenza affecting the respirator...
Influenza A virus infection causes a contagious respiratory illness that poses a threat to human hea...
A series of novel dihydro-alkyloxy-benzyl-oxopyrimidine derivatives were synthesized and evaluated f...
COVID-19, caused by the highly transmissible severe acute respiratory syndrome coronavirus-2 (SARS-C...
Five novel quinolizidine-based alkaloids (1–5) were obtained from the seeds of Sophora alopecuroides...
[eng] Research for new antivirals to treat Influenza A virus infections has gained importance during...
A series of phenanthroquinolizidine alkaloids 1-24 were prepared and first evaluated for their antiv...
The influenza virus represents a permanent global health threat because it circulates not only withi...
Every year, influenza epidemics cause numerous deaths and millions of hospitalizations, but the most...
Despite widespread immunization, influenza still kills thousand of people, and costs to the US, Euro...
A series of phenanthroquinolizidine alkaloids 1–24 were prepared and first evaluated for their antiv...
Influenza is a contagious respiratory acute viral disease characterized by a short incubation period...
In the first part of this overview, we described the life cycle of the influenza virus and the pharm...
To investigate the influence of the variation of the original skeletons of natural phenanthroindo/qu...
<div><p>A series of phenanthroquinolizidine alkaloids <b>1</b>–<b>24</b> were prepared and first eva...
Influenza virus is the main cause of an infectious disease called influenza affecting the respirator...
Influenza A virus infection causes a contagious respiratory illness that poses a threat to human hea...
A series of novel dihydro-alkyloxy-benzyl-oxopyrimidine derivatives were synthesized and evaluated f...
COVID-19, caused by the highly transmissible severe acute respiratory syndrome coronavirus-2 (SARS-C...
Five novel quinolizidine-based alkaloids (1–5) were obtained from the seeds of Sophora alopecuroides...
[eng] Research for new antivirals to treat Influenza A virus infections has gained importance during...
A series of phenanthroquinolizidine alkaloids 1-24 were prepared and first evaluated for their antiv...
The influenza virus represents a permanent global health threat because it circulates not only withi...
Every year, influenza epidemics cause numerous deaths and millions of hospitalizations, but the most...
Despite widespread immunization, influenza still kills thousand of people, and costs to the US, Euro...
A series of phenanthroquinolizidine alkaloids 1–24 were prepared and first evaluated for their antiv...
Influenza is a contagious respiratory acute viral disease characterized by a short incubation period...
In the first part of this overview, we described the life cycle of the influenza virus and the pharm...
To investigate the influence of the variation of the original skeletons of natural phenanthroindo/qu...
<div><p>A series of phenanthroquinolizidine alkaloids <b>1</b>–<b>24</b> were prepared and first eva...
Influenza virus is the main cause of an infectious disease called influenza affecting the respirator...